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Protein Coding Gene : Mapkapk5 MAP kinase-activated protein kinase 5

Primary Identifier  MGI:1333110 Organism  mouse, laboratory
Chromosome  5 NCBI Gene Number  17165
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Enables mitogen-activated protein kinase binding activity; p53 binding activity; and protein serine/threonine kinase activity. Involved in Ras protein signal transduction; negative regulation of TOR signaling; and stress-induced premature senescence. Acts upstream of or within positive regulation of dendritic spine development. Located in cytoplasm; nucleus; and septin cytoskeleton. Part of protein-containing complex. Is expressed in several structures, including brain; lung; metanephros; and nasal epithelium. Orthologous to human MAPKAPK5 (MAPK activated protein kinase 5).
PHENOTYPE: Homozygous mutant mice are viable, fertile, and show no overt abnormalities. [provided by MGI curators]
  • synonyms:
  • MK5,
  • MAP kinase-activated protein kinase 5,
  • PRAK,
  • Mapkapk5

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

2 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

13 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For