| First Author | Fakis G | Year | 2000 |
| Journal | Cytogenet Cell Genet | Volume | 90 |
| Issue | 1-2 | Pages | 134-8 |
| PubMed ID | 11060463 | Mgi Jnum | J:58758 |
| Mgi Id | MGI:1349563 | Doi | 10.1159/000015648 |
| Citation | Fakis G, et al. (2000) Chromosomal mapping of the genes for murine arylamine N-actyltransferases (NATs), enzymes involved in the metabolism of carcinogens: identification of a novel upstream noncoding exon for murine Nat2. Cytogenet Cell Genet 90(1-2):134-8 |
| abstractText | Arylamine N-acetyltransferases (NATs) have been extensively studied as enzymes which N-acetylate arylamines and hydrazines, including several drugs and carcinogens. There are three functional genes in mice, Nat1, Nat2 and Nat3, encoding for three NAT isoenzymes. Nat2 is polymorphic, with certain inbred mouse strains classified either as "fast" or "slow" acetylators. Nat1 and Nat3 seem to be monomorphic. Nat1 and Nat2 have previously been reported to localise on chromosome 8, at 31cM, based on linkage with the gene for esterase 1 (Es-1) (Mattano et al., 1988, J Hered 79:430-433). Here, we report that Nat3 co-localises with Nat1 and Nat2 on the same PAC clone and provide information about cytogenetic localisation of the Nat locus in region B3.1-B3.3 of murine chromosome 8. |
