| First Author | Kuteeva E | Year | 2005 |
| Journal | Neuropeptides | Volume | 39 |
| Issue | 3 | Pages | 299-304 |
| PubMed ID | 15944026 | Mgi Jnum | J:128881 |
| Mgi Id | MGI:3768220 | Doi | 10.1016/j.npep.2005.01.004 |
| Citation | Kuteeva E, et al. (2005) Behavioural characterisation of transgenic mice overexpressing galanin under the PDGF-B promoter. Neuropeptides 39(3):299-304 |
| abstractText | The behavioural phenotype of transgenic mice (3-5-months old) overexpressing galanin (GalOE mice) under the platelet-derived growth factor B (PDGF-B) promoter was evaluated in a battery of tests, including locomotor cages, light-dark exploration test, elevated plus-maze and the Porsolt forced swim test. Learning and memory were assessed in the Morris water maze task. GalOE mice showed a slight increase in spontaneous locomotor activity assessed in the locomotor cages, but the amphetamine-induced increase in locomotor activity was somewhat lower in GalOE mice. Anxiety-like behaviour in light-dark exploration and elevated plus-maze tests did not differ between genotypes. In the Porsolt forced swim test, GalOE mice displayed an increased time of immobility, indicative of increased learned helplessness possibly reflecting increased stress-susceptibility and/or depression-like behaviour. GalOE mice showed normal learning and memory retention in the Morris water maze tasks. These data support the hypothesis that galanin may have a role in functions related to mood states, including affective disorders. |
