| Primary Identifier | IPR033238 | Type | Family |
| Short Name | BCL10/E10 |
| description | This entry includes animal B-cell lymphoma/leukemia 10 (BCL10) and Equine herpesvirus protein E10.In lymphoid cells BCL10 plays a critical role in the activation of the transcription factor nuclear factor kappa B (NF-kB) downstream of a variety of immune receptors, including the TCR, B cell receptor, NK-cell receptors, C type family lectin receptors, Ig family receptors and G protein-coupled receptors [, , ]. Activation of NF-kB through receptor-mediated pathways requires BCL10 to form a complex (known as CBM) with the paracaspase MALT1 and with CARD-containing adaptor protein CARMA []. BCL10 is involved in the regulation of apoptosis; a BCL10 gene tanslocation is found in mucosa-associated lymphoid tissue (MALT) lymphomas [, ]. BCL10 is involved in the adaptive and innate immune response [, ]. Equine herpesvirus protein E10 (v-E10) is the viral homologue of the BCL10 protein []. It induces membrane recruitment of cellular BCL10, and this induces TRAF-mediated NF-kappaB activation []. |
