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Allele : Tg(Thy1-APPSweAut)A7Tiwa transgene insertion A7, Takeshi Iwatsubo
Primary Identifier  MGI:5559448 Allele Type  Transgenic
Attribute String  Inserted expressed sequence Gene  Tg(Thy1-APPSweAut)A7Tiwa
Strain of Origin  Not Specified Is Recombinase  false
Is Wild Type  false
molecularNote  This transgene expresses the human APP695 harboring the Swedish K670N and M671L (Swe) and the Austrian T714I (Aut) familial Alzheimer disease mutations in neurons under the control of the Thy1.2 promoter. Immunoblotting shows that expression of transgenic human APP proteins is about 1.4 fold that of endogenous murine App.
  • mutations:
  • Insertion
  • synonyms:
  • Tg(Thy1-APP*K670N*M671L*T714I)A7Tiwa,
  • A7 APP Tg,
  • A7 APP Tg,
  • Tg(Thy1-APP*Swe*Aut)A7Tiwa,
  • Tg(Thy1-APP*K670N*M671L*T714I)A7Tiwa,
  • Tg(Thy1-APP*Swe*Aut)A7Tiwa
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

10 Publication categories

Trail: Allele




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