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Gene Segment : Iglc1 immunoglobulin lambda constant 1

Primary Identifier	MGI:99546	Organism	mouse, laboratory
Chromosome	16	Mgi Type	gene segment

description

FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Predicted to enable antigen binding activity. Predicted to be involved in immunoglobulin mediated immune response. Located in external side of plasma membrane. Part of B cell receptor complex. Orthologous to several human genes including IGLC6 (immunoglobulin lambda constant 6).
PHENOTYPE: Knock-in mice homozygous for a PGK-neo insertion and a serine codon mutation show altered kappa and lambda B cell number. Knock-in mice heterozygous for the same PGK-neo insertion and a valine mutation show abnormal immunoglobulin light chain V-J joiningwhile homozygotes show reduced B cell number. [provided by MGI curators]

synonyms:
Iglc1,
Igl-C1,
MGD-MRK-16324,
immunoglobulin lambda constant 1,
Clambda1,
immunoglobulin lambda chain, constant region 1

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

2 Involved In Mutations

Trail: GeneSegment

0 Strain

0 Transcripts

0 Transgenic Expressors

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

26 Pathways