| Primary Identifier | MGI:95915 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 14991 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables peptide antigen binding activity. Acts upstream of or within several processes, including positive regulation of biosynthetic process; positive regulation of leukocyte mediated cytotoxicity; and response to bacterium. Located in external side of plasma membrane. Part of MHC class Ib protein complex. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system; liver; and lung. Human ortholog(s) of this gene implicated in asthma and hepatitis C. Orthologous to human HLA-G (major histocompatibility complex, class I, G). PHENOTYPE: At least three alleles are known for this locus: allele a, found in C57BL/6, C3H-Pgk1a, NZO and NMRI, and allele c, found in M. spretus determine distinct antigen specificities. Allele b, found in M.m. castaneus results in absence of antigen. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
