| First Author | Carneiro P | Year | 2012 |
| Journal | FEBS Lett | Volume | 586 |
| Issue | 18 | Pages | 2981-9 |
| PubMed ID | 22841718 | Mgi Jnum | J:188707 |
| Mgi Id | MGI:5441647 | Doi | 10.1016/j.febslet.2012.07.045 |
| Citation | Carneiro P, et al. (2012) E-cadherin dysfunction in gastric cancer--cellular consequences, clinical applications and open questions. FEBS Lett 586(18):2981-9 |
| abstractText | E-cadherin plays a major role in cell-cell adhesion and inactivating germline mutations in its encoding gene predispose to hereditary diffuse gastric cancer. Evidence indicates that aside from its recognized role in early tumourigenesis, E-cadherin is also pivotal for tumour progression, including invasion and metastization. Herein, we discuss E-cadherin alterations found in a cancer context, associated cellular effects and signalling pathways, and we raise new key questions that will impact in the management of GC patients and families. |
