| First Author | Yao W | Year | 2005 |
| Journal | Endocrine | Volume | 26 |
| Issue | 2 | Pages | 117-25 |
| PubMed ID | 15888923 | Mgi Jnum | J:109832 |
| Mgi Id | MGI:3630008 | Doi | 10.1385/ENDO:26:2:117 |
| Citation | Yao W, et al. (2005) Igf-I and postnatal growth of weaver mutant mice. Endocrine 26(2):117-25 |
| abstractText | IGF-I is an anabolic growth factor essential for growth and development, both as a mediator of growth hormone (GH) action and as a local stimulator of cell proliferation and differentiation. Although the importance of IGF-I in postnatal growth has been studied for several decades, its functions in pathological states are not fully understood. The weaver (wv) mutant mouse is a commonly used model for studying hereditary cerebellar ataxia and provides us with an opportunity to study the function of IGF-I in postnatal growth during neurodegeneration. In prepubertal wv mice, we found a parallel decrease in body weight and serum IGF-I. This parallel relationship was maintained in females, but not in males, as wv mice entered puberty. Interestingly, we found an increase in the levels of circulating IGF-I and hepatic mRNA preceded the catch-up of body weight of pubertal male wv mice. The increase in IGF-I levels coincided with a surge of circulating androgen at the onset of male puberty, suggesting that androgen might trigger the increase in IGF-I production in the pubertal and adult male wv mice. Overall, our results support the concept that IGF-I plays an important role in postnatal growth during and after neurodegeneration of wv mice. In addition, IGF-I's regulation of systemic growth during and after puberty is likely modulated by androgen in male wv mice. |
