| Primary Identifier | MGI:104294 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 22174 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable phosphatidylinositol 3-kinase binding activity; transmembrane receptor protein tyrosine kinase activity; and virus receptor activity. Involved in several processes, including phosphatidylinositol 3-kinase/protein kinase B signal transduction; platelet aggregation; and regulation of defense response. Acts upstream of or within several processes, including nervous system development; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and substrate adhesion-dependent cell spreading. Predicted to be located in cell surface; endoplasmic reticulum membrane; and nuclear envelope. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; limb; and sensory organ. Used to study autoimmune disease. Orthologous to human TYRO3 (TYRO3 protein tyrosine kinase). PHENOTYPE: Homozygous mutant mice are phenotypically normal, however in conjunction with mutations in other related receptor tyrosine kinases, mutations of this gene results in fertility defects, autoimmunity, and aberrant apoptosis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
