| First Author | Matsuo N | Year | 2008 |
| Journal | Science | Volume | 319 |
| Issue | 5866 | Pages | 1104-7 |
| PubMed ID | 18292343 | Mgi Jnum | J:131711 |
| Mgi Id | MGI:3774233 | Doi | 10.1126/science.1149967 |
| Citation | Matsuo N, et al. (2008) Spine-type-specific recruitment of newly synthesized AMPA receptors with learning. Science 319(5866):1104-7 |
| abstractText | The stabilization of long-term memories requires de novo protein synthesis. How can proteins, synthesized in the soma, act on specific synapses that participate in a given memory? We studied the dynamics of newly synthesized AMPA-type glutamate receptors (AMPARs) induced with learning using transgenic mice expressing the GluR1 subunit fused to green fluorescent protein (GFP-GluR1) under control of the c-fos promoter. We found learning-associated recruitment of newly synthesized GFP-GluR1 selectively to mushroom-type spines in adult hippocampal CA1 neurons 24 hours after fear conditioning. Our results are consistent with a 'synaptic tagging' model to allow activated synapses to subsequently capture newly synthesized receptor and also demonstrate a critical functional distinction in the mushroom spines with learning. |
