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Protein Coding Gene : Ncan neurocan

Primary Identifier  MGI:104694 Organism  mouse, laboratory
Chromosome  8 NCBI Gene Number  13004
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable calcium ion binding activity; carbohydrate binding activity; and hyaluronic acid binding activity. Involved in modulation of chemical synaptic transmission and regulation of postsynapse organization. Acts upstream of or within regulation of synapse structural plasticity. Is active in GABA-ergic synapse; glutamatergic synapse; and perisynaptic extracellular matrix. Is expressed in lower jaw; nervous system; and sensory organ. Orthologous to human NCAN (neurocan).
PHENOTYPE: Mice homozygous for targeted null mutations are viable and fertile and exhibit normal behavior and brain anatomy; however, mild defects in long term potentiation were noted. [provided by MGI curators]
  • synonyms:
  • chondroitin sulfate proteoglycan 3,
  • TGFbeta-induced transcript, brain,
  • MGD-MRK-27057,
  • Cspg3,
  • chondroitin sulfate proteoglycan 3, related sequence,
  • Tgfbit,
  • MGI:1097681,
  • Ncan,
  • MGI:101837,
  • neurocan,
  • MGD-MRK-18658,
  • Cspg3-rs

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

1 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

11 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For