| First Author | Tybulewicz VL | Year | 1991 |
| Journal | Cell | Volume | 65 |
| Issue | 7 | Pages | 1153-63 |
| PubMed ID | 2065352 | Mgi Jnum | J:72875 |
| Mgi Id | MGI:2153797 | Doi | 10.1016/0092-8674(91)90011-m |
| Citation | Tybulewicz VL, et al. (1991) Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell 65(7):1153-63 |
| abstractText | The c-abl proto-oncogene, which encodes a cytoplasmic protein-tyrosine kinase, is expressed throughout murine gestation and ubiquitously in adult mouse tissues. However, its levels are highest in thymus, spleen, and testes. To examine the in vivo role of c-abl, the gene was disrupted in embryonic stem cells, and the resulting genetically modified cells were used to establish a mouse strain carrying the mutation. Most mice homozygous for the c-abl mutation became runted and died 1 to 2 weeks after birth. In addition, many showed thymic and splenic atrophy and a T and B cell lymphopenia. |
