| First Author | Heyer J | Year | 1997 |
| Journal | Immunobiology | Volume | 198 |
| Issue | 1-3 | Pages | 162-9 |
| PubMed ID | 9442388 | Mgi Jnum | J:45252 |
| Mgi Id | MGI:1194698 | Doi | 10.1016/S0171-2985(97)80037-X |
| Citation | Heyer J, et al. (1997) Inefficient termination of antigen responses in NF-ATp-deficient mice. Immunobiology 198(1-3):162-9 |
| abstractText | In order to elucidate the role of NF-ATp, one of the most prominent members of family of NF-AT transcription factors in peripheral T lyn phocytes, in T cell activation and differentiation we created NF-ATp-deficient mice by gene targeting. Such NF-ATp-/- mice are born and appear to develop a normal immune system. Apart from clear-cut defects in the synthesis of mRNAs for Th2-type lymphokines, such as IL-4, IL-5, IL-10 and IL-13, in primary and secondary stimulations of spleen cells in vitro, of a distinct impaired deletion of V beta 11+/CD4+ T lymphocytes from these mice was detected after superantigen injection. Moreover, NF-ATp-/- mice older than 6 weeks show an 2-5 fold increase in number of lymphocytes. This is correlated with an increased expression of activation markers CD44 and CD69 and decreased expression of CD62. |
