Primary Identifier | MGI:4442944 | Allele Type | Targeted |
Attribute String | Conditional ready, Dominant negative, Humanized sequence, Inserted expressed sequence | Gene | Mapt |
Transmission | Germline | Strain of Origin | 129S4/SvJae |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Exon 1 was replaced with a vector containing a floxed STOP cassette, HA-tagged human cDNA with a nucleotide substitution resulting in the amino acid substitution of threonine with asparagine at position 19, and a neo cassette. Cre mediated recombination is required for the expression of a dominant-negative form. |