| First Author | Xiong Y | Year | 1992 |
| Journal | Genomics | Volume | 13 |
| Issue | 3 | Pages | 575-84 |
| PubMed ID | 1386336 | Mgi Jnum | J:1252 |
| Mgi Id | MGI:49782 | Doi | 10.1016/0888-7543(92)90127-e |
| Citation | Xiong Y, et al. (1992) Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins. Genomics 13(3):575-84 |
| abstractText | A human D-type cyclin gene (CCND1/cyclin D1/PRAD1) was previously isolated by virtue of its ability to complement a triple G1 cyclin (Cln) deficiency of Saccharomyces cerevisiae and was also identified as a candidate BCL1 oncogene. We now report the molecular cloning of two additional human D-type cyclin genes, CCND2 (cyclin D2) and CCND3 (cyclin D3). All three human D-type cyclin genes encode small (33-34 kDa) proteins that share an average of 57% identity over the entire coding region and 78% in the cyclin box. The D-type cyclins are most closely related to cyclin A (39% identity) and cyclin E (36%), followed by cyclin B (29%) and cyclin C (21%). Isolation and characterization of genomic clones revealed two pseudogenes corresponding to CCND2 and CCND3, respectively. All three cyclin D genes are interrupted by an intron at the same position. CCND2 has been mapped to chromosome 12p13, and CCND3 has been mapped to chromosome 6p21. |
