| First Author | Arnould M | Year | 2004 |
| Journal | FEBS Lett | Volume | 568 |
| Issue | 1-3 | Pages | 89-93 |
| PubMed ID | 15196926 | Mgi Jnum | J:91107 |
| Mgi Id | MGI:3045941 | Doi | 10.1016/j.febslet.2004.05.012 |
| Citation | Arnould M, et al. (2004) The G-protein-coupled CCK2 receptor associates with phospholipase Cgamma1. FEBS Lett 568(1-3):89-93 |
| abstractText | In ElasCCK2 transgenic mice expressing cholecystokinin (CCK2) receptor in acinar cells, pancreatic phenotypic alterations and preneoplastic lesions are observed. We determined whether activation of phospholipase C gamma1 (PLCgamma1), known to contribute to the tumorigenesis pathophysiology, could take place as a new signaling pathway induced by the CCK2 receptor. Overexpression and activation of the PLCgamma1 in response to gastrin was observed in acinar cells. The possibility that the C-terminal tyrosine 438 of the CCK2 receptor associates with the SH2 domains of PLCgamma1 was examined. A specific interaction was demonstrated using surface plasmon resonance, confirmed in a cellular system and by molecular modeling. |
