| First Author | Murray JC | Year | 1992 |
| Journal | Nat Genet | Volume | 2 |
| Issue | 1 | Pages | 46-9 |
| PubMed ID | 1303248 | Mgi Jnum | J:2166 |
| Mgi Id | MGI:50690 | Doi | 10.1038/ng0992-46 |
| Citation | Murray JC, et al. (1992) Linkage of Rieger syndrome to the region of the epidermal growth factor gene on chromosome 4. Nat Genet 2(1):46-9 |
| abstractText | Rieger syndrome is an autosomal dominant disorder of morphogenesis in which previous cytogenetic arrangements have suggested chromosome 4 as a candidate chromosome. Using a group of highly polymorphic short tandem repeat polymorphisms (STRP), including a new tetranucleotide repeat for epidermal growth factor (EGF), significant linkage of Rieger syndrome to 4q markers has been identified. Tight linkage to EGF supports its role as a candidate gene, although a recombinant in an unaffected individual has been identified. This study demonstrates the utility of using polymorphic STRP markers when only a limited number of small families are available for study. |
