| Primary Identifier | IPR019003 | Type | Family |
| Short Name | AMER |
| description | This entry includes APC membrane recruitment protein 1/2/3 (Amer1/2/3). Amer1, also known as WTX, binds to the tumour suppressor adenomatous polyposis coli and acts as an inhibitor of Wnt signaling by inducing beta-catenin degradation []. Amer2 is a negative regulator of Wnt/beta-catenin signaling involved in neuroectodermal patterning [].WTX is a novel gene mutated in a proportion of Wilms' tumors and in patients suffering from sclerosing bone dysplasia []. |
