| First Author | Yoshida M | Year | 2001 |
| Journal | Biochem Biophys Res Commun | Volume | 281 |
| Issue | 1 | Pages | 94-100 |
| PubMed ID | 11178965 | Mgi Jnum | J:67555 |
| Mgi Id | MGI:1930846 | Doi | 10.1006/bbrc.2001.4311 |
| Citation | Yoshida M, et al. (2001) Identification of two rodent genes encoding homologues to seminal vesicle autoantigen: a gene family including the gene for prolactin-inducible protein. Biochem Biophys Res Commun 281(1):94-100 |
| abstractText | We cloned two new paralogous genes that encode proteins homologous to seminal vesicle autoantigen (SVA) in rodents. The open reading frame of one mouse gene encodes a polypeptide consisting of 151 amino acid residues which has 43% identity to SVA. RT-PCR analysis showed selective expression in the colon, and thus the protein was tentatively named 'SVA-like protein in the colon (SLP-C)'. The other mouse gene has an open reading frame encoding 144 amino acid residues with 46 and 65% identity to SVA and SLP-C, respectively. Expression of this gene was detected in the mammary, submaxillary, parotid, and lacrimal glands, and this protein was named 'SLP in the mammary gland (SLP-M)'. Orthologs of both genes were also found in rats. The three homologous genes coding for SVA, SLP-C, and SLP-M may have been generated by gene duplication with divergence of tissue expression in the course of evolution. They comprise a unique structurally-related gene family. Moreover, these genes share significant sequence homology with that of another secretory glycoprotein, prolactin-inducible protein. |
