| First Author | Hilgendorf KI | Year | 2019 |
| Journal | Cell | Volume | 179 |
| Issue | 6 | Pages | 1289-1305.e21 |
| PubMed ID | 31761534 | Mgi Jnum | J:282613 |
| Mgi Id | MGI:6383338 | Doi | 10.1016/j.cell.2019.11.005 |
| Citation | Hilgendorf KI, et al. (2019) Omega-3 Fatty Acids Activate Ciliary FFAR4 to Control Adipogenesis. Cell 179(6):1289-1305.e21 |
| abstractText | Adult mesenchymal stem cells, including preadipocytes, possess a cellular sensory organelle called the primary cilium. Ciliated preadipocytes abundantly populate perivascular compartments in fat and are activated by a high-fat diet. Here, we sought to understand whether preadipocytes use their cilia to sense and respond to external cues to remodel white adipose tissue. Abolishing preadipocyte cilia in mice severely impairs white adipose tissue expansion. We discover that TULP3-dependent ciliary localization of the omega-3 fatty acid receptor FFAR4/GPR120 promotes adipogenesis. FFAR4 agonists and omega-3 fatty acids, but not saturated fatty acids, trigger mitosis and adipogenesis by rapidly activating cAMP production inside cilia. Ciliary cAMP activates EPAC signaling, CTCF-dependent chromatin remodeling, and transcriptional activation of PPARgamma and CEBPalpha to initiate adipogenesis. We propose that dietary omega-3 fatty acids selectively drive expansion of adipocyte numbers to produce new fat cells and store saturated fatty acids, enabling homeostasis of healthy fat tissue. |
