| First Author | Naeher D | Year | 2007 |
| Journal | J Exp Med | Volume | 204 |
| Issue | 11 | Pages | 2553-9 |
| PubMed ID | 17938233 | Mgi Jnum | J:126145 |
| Mgi Id | MGI:3760595 | Doi | 10.1084/jem.20070254 |
| Citation | Naeher D, et al. (2007) A constant affinity threshold for T cell tolerance. J Exp Med 204(11):2553-9 |
| abstractText | T cell tolerance depends on the T cell receptor's affinity for peptide/major histocompatibility complex (MHC) ligand; this critical parameter determines whether a thymocyte will be included (positive selection) or excluded (negative selection) from the T cell repertoire. A quantitative analysis of ligand binding was performed using an experimental system permitting receptor-coreceptor interactions on live cells under physiological conditions. Using three transgenic mouse strains expressing distinct class I MHC-restricted T cell receptors, we determined the affinity that defines the threshold for negative selection. The affinity threshold for self-tolerance appears to be a constant for cytotoxic T lymphocytes. |
