| First Author | Wu CC | Year | 2010 |
| Journal | Protein Cell | Volume | 1 |
| Issue | 6 | Pages | 573-83 |
| PubMed ID | 21170151 | Mgi Jnum | J:309913 |
| Mgi Id | MGI:6709155 | Doi | 10.1007/s13238-010-0075-1 |
| Citation | Wu CC, et al. (2010) p38gamma regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage. Protein Cell 1(6):573-83 |
| abstractText | In eukaryotic cells, DNA damage triggers activation of checkpoint signaling pathways that coordinate cell cycle arrest and repair of damaged DNA. These DNA damage responses serve to maintain genome stability and prevent accumulation of genetic mutations and development of cancer. The p38 MAPK was previously implicated in cellular responses to several types of DNA damage. However, the role of each of the four p38 isoforms and the mechanism for their involvement in DNA damage responses remained poorly understood. In this study, we demonstrate that p38gamma, but not the other p38 isoforms, contributes to the survival of UV-treated cells. Deletion of p38gamma sensitizes cells to UV exposure, accompanied by prolonged S phase cell cycle arrest and increased rate of apoptosis. Further investigation reveal that p38gamma is essential for the optimal activation of the checkpoint signaling caused by UV, and for the efficient repair of UV-induced DNA damage. These findings have established a novel role of p38gamma in UV-induced DNA damage responses, and suggested that p38gamma contributes to the ability of cells to cope with UV exposure by regulating the checkpoint signaling pathways and the repair of damaged DNA. |
