| First Author | Tsuji T | Year | 2022 |
| Journal | Int J Mol Sci | Volume | 23 |
| Issue | 10 | PubMed ID | 35628137 |
| Mgi Jnum | J:338958 | Mgi Id | MGI:7283144 |
| Doi | 10.3390/ijms23105321 | Citation | Tsuji T, et al. (2022) Transplantation of Brown Adipose Tissue with the Ability of Converting Omega-6 to Omega-3 Polyunsaturated Fatty Acids Counteracts High-Fat-Induced Metabolic Abnormalities in Mice. Int J Mol Sci 23(10) |
| abstractText | A balanced omega (omega)-6/omega-3 polyunsaturated fatty acids (PUFAs) ratio has been linked to metabolic health and the prevention of chronic diseases. Brown adipose tissue (BAT) specializes in energy expenditure and secretes signaling molecules that regulate metabolism via inter-organ crosstalk. Recent studies have uncovered that BAT produces different PUFA species and circulating oxylipin levels are correlated with BAT-mediated energy expenditure in mice and humans. However, the impact of BAT omega-6/omega-3 PUFAs on metabolic phenotype has not been fully elucidated. The Fat-1 transgenic mice can convert omega-6 to omega-3 PUFAs. Here, we demonstrated that mice receiving Fat-1 BAT transplants displayed better glucose tolerance and higher energy expenditure. Expression of genes involved in thermogenesis and nutrient utilization was increased in the endogenous BAT of mice receiving Fat-1 BAT, suggesting that the transplants may activate recipients' BAT. Using targeted lipidomic analysis, we found that the levels of several omega-6 oxylipins were significantly reduced in the circulation of mice receiving Fat-1 BAT transplants than in mice with wild-type BAT transplants. The major altered oxylipins between the WT and Fat-1 BAT transplantation were omega-6 arachidonic acid-derived oxylipins via the lipoxygenase pathway. Taken together, these findings suggest an important role of BAT-derived oxylipins in combating obesity-related metabolic disorders. |
