| Type | MGI:General | Description | mice develop atypical proliferative lesions indicating prostatic intraepithelial neoplasia (mPIN) as early as 8 weeks of age 40.9% of mice exhibit mPIN lesions mPIN lesions are mainly cribriform structures with occasional stratification of cells, papilliferous structures and tufts of cells atypical epithelial cells that are irregular, larger than adjacent normal cells, and lacking normal polarity are seen in all prostatic lobes, including anterior, dorsal and ventral prostate foci of atypical cells partially fill the lumen of the ducts mice exhibit intraluminal glands forming within the original glands in the dysplastic lesions |
