| First Author | Tellier J | Year | 2016 |
| Journal | Nat Immunol | Volume | 17 |
| Issue | 3 | Pages | 323-30 |
| PubMed ID | 26779600 | Mgi Jnum | J:259001 |
| Mgi Id | MGI:6140971 | Doi | 10.1038/ni.3348 |
| Citation | Tellier J, et al. (2016) Blimp-1 controls plasma cell function through the regulation of immunoglobulin secretion and the unfolded protein response. Nat Immunol 17(3):323-30 |
| abstractText | Plasma cell differentiation requires silencing of B cell transcription, while it establishes antibody-secretory function and long-term survival. The transcription factors Blimp-1 and IRF4 are essential for the generation of plasma cells; however, their function in mature plasma cells has remained elusive. We found that while IRF4 was essential for the survival of plasma cells, Blimp-1 was dispensable for this. Blimp-1-deficient plasma cells retained their transcriptional identity but lost the ability to secrete antibody. Blimp-1 regulated many components of the unfolded protein response (UPR), including XBP-1 and ATF6. The overlap in the functions of Blimp-1 and XBP-1 was restricted to that response, with Blimp-1 uniquely regulating activity of the kinase mTOR and the size of plasma cells. Thus, Blimp-1 was required for the unique physiological ability of plasma cells that enables the secretion of protective antibody. |
