| Type | MGI:General | Description | 3 and 12 month old mutants exhibit altered dopamine release and reuptake patterns; the peak amplitude, or amount, of dopamine release induced by depolarization with a fixed amount of locally applied KCl is reduced dopamine uptake is reduced at 3 and 12 months of age and release rate is lower at 3 months of age, with a trend for reduction at 12 months of age the total dopamine load is reduced at 12 months of age indicating reduced dopamine transmission in the striatum |
