| First Author | Kawamoto S | Year | 2012 |
| Journal | Science | Volume | 336 |
| Issue | 6080 | Pages | 485-9 |
| PubMed ID | 22539724 | Mgi Jnum | J:183986 |
| Mgi Id | MGI:5319705 | Doi | 10.1126/science.1217718 |
| Citation | Kawamoto S, et al. (2012) The inhibitory receptor PD-1 regulates IgA selection and bacterial composition in the gut. Science 336(6080):485-9 |
| abstractText | Immunoglobulin A (IgA) is essential to maintain the symbiotic balance between gut bacterial communities and the host immune system. Here we provide evidence that the inhibitory co-receptor programmed cell death-1 (PD-1) regulates the gut microbiota through appropriate selection of IgA plasma cell repertoires. PD-1 deficiency generates an excess number of T follicular helper (T(FH)) cells with altered phenotypes, which results in dysregulated selection of IgA precursor cells in the germinal center of Peyer's patches. Consequently, the IgAs produced in PD-1-deficient mice have reduced bacteria-binding capacity, which causes alterations of microbial communities in the gut. Thus, PD-1 plays a critical role in regulation of antibody diversification required for the maintenance of intact mucosal barrier. |
