| Primary Identifier | MGI:1913277 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 58799 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable transmembrane transporter binding activity. Involved in locomotory exploration behavior. Predicted to be located in nucleus and perinuclear region of cytoplasm. Predicted to be part of Cul4A-RING E3 ubiquitin ligase complex. Is expressed in several structures, including alimentary system; aorta; central nervous system; eye; and genitourinary system. Used to study autosomal recessive intellectual developmental disorder. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 2. Orthologous to human CRBN (cereblon). PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired contextual conditioning behavior. Mice homozygous for another knock-out allele exhibit resistance to diet-induced obesity, liver steatosis, glucose intolerance and insulin resistance. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
