| First Author | Hardin-Pouzet H | Year | 1996 |
| Journal | Brain Res Mol Brain Res | Volume | 37 |
| Issue | 1-2 | Pages | 324-8 |
| PubMed ID | 8738168 | Mgi Jnum | J:37592 |
| Mgi Id | MGI:84983 | Doi | 10.1016/0169-328x(95)00327-o |
| Citation | Hardin-Pouzet H, et al. (1996) Glucocorticoid upregulation of glutamate dehydrogenase gene expression in vitro in astrocytes. Brain Res Mol Brain Res 37(1-2):324-8 |
| abstractText | Glutamate, the major excitatory neurotransmitter, is preferentially catabolized in astrocytes by glutamate dehydrogenase (GDH). Treatment of an astrocytic cell line with hydrocortisone (10(-5) M) resulted in increased expression of GDH mRNA. Transfection of the cells with truncated parts of the GDH promoter showed that genomic responsive elements activated by hydrocortisone are localized in the -557/+1 region of the promoter. This control of GDH expression by glucocorticoids may be involved in their protective effect against glutamate excitotoxicity. |
