| First Author | Merkenschlager J | Year | 2023 |
| Journal | Nat Commun | Volume | 14 |
| Issue | 1 | Pages | 6944 |
| PubMed ID | 37907454 | Mgi Jnum | J:342405 |
| Mgi Id | MGI:7546367 | Doi | 10.1038/s41467-023-41880-9 |
| Citation | Merkenschlager J, et al. (2023) Continually recruited naive T cells contribute to the follicular helper and regulatory T cell pools in germinal centers. Nat Commun 14(1):6944 |
| abstractText | Follicular helper T cells (T(FH)) mediate B cell selection and clonal expansion in germinal centers (GCs), and follicular regulatory T cells (T(FR)) prevent the emergence of self-reactive B cells and help to extinguish the reaction. Here we show that GC reactions continually recruit T cells from both the naive conventional and naive thymic regulatory T cell (Treg) repertoires. In the early GC, newly recruited T cells develop into T(FH), whereas cells entering during the contraction phase develop into T(FR) cells that contribute to GC dissolution. The T(FR) fate decision is associated with decreased antigen availability and is modulated by slow antigen delivery or mRNA vaccination. Thus, invasion of ongoing GCs by newly developing T(FH) and T(FR) helps remodel the GC based on antigen availability. |
