| First Author | Cooper AB | Year | 2006 |
| Journal | Nat Immunol | Volume | 7 |
| Issue | 5 | Pages | 489-97 |
| PubMed ID | 16582912 | Mgi Jnum | J:112393 |
| Mgi Id | MGI:3656195 | Doi | 10.1038/ni1324 |
| Citation | Cooper AB, et al. (2006) A unique function for cyclin D3 in early B cell development. Nat Immunol 7(5):489-97 |
| abstractText | During hematopoiesis, stem cell proliferation is dependent on expression of the D-type cyclins. However, little is known about how each cyclin D contributes to the development of specific hematopoietic lineages. Here, analysis of Ccnd1(-/-), Ccnd2(-/-), Ccnd3(-/-) and Ccnd2(-/-)Ccnd3(-/-) mice showed that cyclin D3 was uniquely required for the development of pre-B cells. Transcription of Ccnd3 was dependent on expression of the common gamma-chain. In contrast, expression of the pre-B cell receptor and activation of 'downstream' signaling pathways prevented proteasome-mediated degradation of cyclin D3. Cyclin D3 has a key function in B cell development by integrating cytokine and pre-B cell receptor-dependent signals to expand the pool of pre-B cells that have successfully rearranged immunoglobulin heavy chain. |
