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Protein Coding Gene : Kmt2e lysine (K)-specific methyltransferase 2E

Primary Identifier  MGI:1924825 Organism  mouse, laboratory
Chromosome  5 NCBI Gene Number  69188
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable enzyme binding activity; methylated histone binding activity; and transcription coactivator activity. Involved in several processes, including erythrocyte differentiation; neutrophil activation; and neutrophil mediated immunity. Predicted to be located in nuclear body. Predicted to be part of Rpd3L-Expanded complex; Set3 complex; and euchromatin. Is expressed in several structures, including alimentary system; eye; heart; metanephros; and nervous system. Human ortholog(s) of this gene implicated in autistic disorder and cervical cancer. Orthologous to human KMT2E (lysine methyltransferase 2E (inactive)).
PHENOTYPE: Mice homozygous for a null allele exhibit neonatal and postnatal lethality, reduced fertility and growth, and abnormal lymphopoiesis. [provided by MGI curators]
  • synonyms:
  • MGI:1916438,
  • D230038D11Rik,
  • 9530077A04Rik,
  • Kmt2e,
  • RIKEN cDNA D230038D11 gene,
  • RIKEN cDNA 1810033J14 gene,
  • lysine (K)-specific methyltransferase 2E,
  • myeloid/lymphoid or mixed-lineage leukemia 5,
  • RIKEN cDNA 9530077A04 gene,
  • 1810033J14Rik,
  • Mll5,
  • MGI:1925809

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