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Protein Domain : Growth hormone/erythropoietin receptor, ligand binding

Primary Identifier  IPR015152 Type  Domain
Short Name  Growth/epo_recpt_lig-bind
description  Members of this entry include the growth hormone and erythropoietin receptors. The latter interacts with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signalling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two β-sandwich regions [].

0 Child Features

0 Parent Features

41 Protein Domain Regions