Primary Identifier | MGI:5796558 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Lrba |
Transmission | Germline | Strain of Origin | C57BL/6N |
Is Recombinase | false | Is Wild Type | false |
molecularNote | The third coding exon (also known as exon 4) was removed. Recombination removed the selection cassette. Deletion of exon 3 generates a frameshift after 5% of the coding sequence (149 aa) giving rise to a constitutive knock-out. Immunoblot analysis shows that protein is undetectable in brain and kidney. |