| First Author | Fournier S | Year | 1997 |
| Journal | Immunity | Volume | 6 |
| Issue | 3 | Pages | 327-39 |
| PubMed ID | 9075933 | Mgi Jnum | J:112475 |
| Mgi Id | MGI:3656386 | Doi | 10.1016/s1074-7613(00)80335-0 |
| Citation | Fournier S, et al. (1997) T cell-mediated elimination of B7.2 transgenic B cells. Immunity 6(3):327-39 |
| abstractText | Transgenic mice were generated to explore the effects on lymphoid development and immune function of constitutive expression of murine B7.2 on B and T cells. The number of B lymphocytes in primary and secondary lymphoid tissues is normal in B7.2 transgenic lines expressing low levels of B7.2 on B cells, but markedly reduced in transgenic lines expressing moderate to high levels of the transgene on B cells. This reduction is not due to an intrinsic abnormality of the transgenic B cells, but is rather the consequence of an elimination by an immune mechanism requiring the engagement of CD28 on T cells. Interestingly, during cognate antigen-specific interaction with T cells in vivo, B7.2 transgenic B cells are not eliminated, but proliferate and differentiate normally. Our findings suggest that, in the absence of high affinity ligand for the TCR, the CD28-B7.2 system participates in the regulation of B cell homeostasis. |
