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Publication : Imprinted microRNA genes transcribed antisense to a reciprocally imprinted retrotransposon-like gene.

First Author  Seitz H Year  2003
Journal  Nat Genet Volume  34
Issue  3 Pages  261-2
PubMed ID  12796779 Mgi Jnum  J:84074
Mgi Id  MGI:2665157 Doi  10.1038/ng1171
Citation  Seitz H, et al. (2003) Imprinted microRNA genes transcribed antisense to a reciprocally imprinted retrotransposon-like gene. Nat Genet 34(3):261-2
abstractText  MicroRNAs (miRNAs) are an abundant class of RNAs that are approximately 21-25 nucleotides (nt) long, interact with mRNAs and trigger either translation repression or RNA cleavage (RNA interference, RNAi) depending on the degree of complementarity with their targets. Here we show that the imprinted mouse distal chromosome 12 locus encodes two miRNA genes expressed from the maternally inherited chromosome and antisense to a retrotransposon-like gene (Rtl1) expressed only from the paternal allele.
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