First Author | Seitz H | Year | 2003 |
Journal | Nat Genet | Volume | 34 |
Issue | 3 | Pages | 261-2 |
PubMed ID | 12796779 | Mgi Jnum | J:84074 |
Mgi Id | MGI:2665157 | Doi | 10.1038/ng1171 |
Citation | Seitz H, et al. (2003) Imprinted microRNA genes transcribed antisense to a reciprocally imprinted retrotransposon-like gene. Nat Genet 34(3):261-2 |
abstractText | MicroRNAs (miRNAs) are an abundant class of RNAs that are approximately 21-25 nucleotides (nt) long, interact with mRNAs and trigger either translation repression or RNA cleavage (RNA interference, RNAi) depending on the degree of complementarity with their targets. Here we show that the imprinted mouse distal chromosome 12 locus encodes two miRNA genes expressed from the maternally inherited chromosome and antisense to a retrotransposon-like gene (Rtl1) expressed only from the paternal allele. |