| First Author | Liao XC | Year | 1995 |
| Journal | Immunity | Volume | 3 |
| Issue | 6 | Pages | 757-69 |
| PubMed ID | 8777721 | Mgi Jnum | J:31230 |
| Mgi Id | MGI:78730 | Doi | 10.1016/1074-7613(95)90065-9 |
| Citation | Liao XC, et al. (1995) Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk. Immunity 3(6):757-69 |
| abstractText | Itk is a T cell protein tyrosine kinase (PTK) that, along with Btk and Tee, belongs to a family of cytoplasmic PTKs with N-terminal pleckstrin homology domains. Btk plays a critical role in B lymphocyte development. To determine whether Itk has an analogous role in T lymphocytes, we used gene targeting to prepare mice lacking expression of Itk. Such animals had decreased numbers of mature thymocytes, an effect most clearly observed in mice expressing T cell receptor (TCR) transgenes. Mature T cells from Itk-deficient mice had reduced proliferative responses to allogeneic MHC stimulation and to anti-TCR cross-linking, but responded normally to stimulation with phorbol ester plus ionomycin or with IL-2. These results provide genetic evidence that Itk is involved in T cell development and also suggest that Itk has an important role in proximal events in TCR-mediated signaling pathways. |
