| Primary Identifier | MGI:1917649 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 97064 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables protein homodimerization activity; transcription coactivator activity; and transcription corepressor activity. Involved in heart process; positive regulation of protein localization to nucleus; and tissue homeostasis. Acts upstream of or within several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; kidney development; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; brain; branchial arch; genitourinary system; and heart. Used to study nephronophthisis. Orthologous to human WWTR1 (WW domain containing transcription regulator 1). PHENOTYPE: Mice homozygous for a null mutation display polycystic kidneys, elevated blood urea nitrogen, partial postnatal lethality, premature death, reduced litter sizes, and mildly reduced body size. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
