| First Author | Meixiong J | Year | 2019 |
| Journal | Immunity | Volume | 50 |
| Issue | 5 | Pages | 1163-1171.e5 |
| PubMed ID | 31027996 | Mgi Jnum | J:282447 |
| Mgi Id | MGI:6380955 | Doi | 10.1016/j.immuni.2019.03.013 |
| Citation | Meixiong J, et al. (2019) Activation of Mast-Cell-Expressed Mas-Related G-Protein-Coupled Receptors Drives Non-histaminergic Itch. Immunity 50(5):1163-1171.e5 |
| abstractText | Classical itch studies have focused on immunoglobulin E (IgE)-mediated mast cell activation and histamine release. Recently, members of the Mas-related G-protein-coupled receptor (Mrgpr) family have been identified as mast cell receptors, but their role in itch is unclear. Here, we report that mast cell activation via Mrgprb2 evoked non-histaminergic itch in mice independently of the IgE-Fc epsilon RI (FcepsilonRI)-histamine axis. Compared with IgE-FcepsilonRI stimulation, Mrgprb2 activation of mast cells was distinct in both released substances (histamine, serotonin, and tryptase) and the pattern of activated itch-sensory neurons. Mrgprb2 deficiency decreased itch in multiple preclinical models of allergic contact dermatitis (ACD), a pruritic inflammatory skin disorder, and both mast cell number and PAMP1-20 concentrations (agonist of the human Mrgprb2 homolog, MRGPRX2) were increased in human ACD skin. These findings suggest that this pathway may represent a therapeutic target for treating ACD and mast-cell-associated itch disorders in which antihistamines are ineffective. |
