Primary Identifier | MGI:109521 | Organism | mouse, laboratory |
Chromosome | 14 | NCBI Gene Number | 15558 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Enables protein tyrosine kinase activator activity. Acts upstream of or within positive regulation of fat cell differentiation; positive regulation of phosphate metabolic process; and protein localization to cytoskeleton. Predicted to be located in cell body fiber; dendritic shaft; and neuronal cell body. Predicted to be part of G protein-coupled serotonin receptor complex. Predicted to be active in dendrite; glutamatergic synapse; and synaptic membrane. Predicted to colocalize with neurofilament. Is expressed in several structures, including alimentary system; brain; embryo ectoderm; embryo mesenchyme; and heart. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcoholic psychosis; anorexia nervosa; cocaine dependence; and nicotine dependence. Orthologous to human HTR2A (5-hydroxytryptamine receptor 2A). PHENOTYPE: Mice homozygous for a knock-out allele show altered anxiety-related responses and increased vertical activity. Mice homozygous for a different knock-out allele exhibit abnormal enterocyte, Paneth cell and smooth muscle morphology. [provided by MGI curators] |