Primary Identifier | MGI:1341112 | Organism | mouse, laboratory |
Chromosome | 14 | NCBI Gene Number | 11546 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Enables NAD+ ADP-ribosyltransferase activity. Involved in decidualization. Acts upstream of or within base-excision repair and extrinsic apoptotic signaling pathway. Located in nucleolus and nucleoplasm. Is expressed in several structures, including central nervous system; gonad; liver; retina; and thymus. Orthologous to human PARP2 (poly(ADP-ribose) polymerase 2). PHENOTYPE: Homozygous mutant animals are sensitive to gamma radiation. Epithelial crypt degeneration and DNA repair deficiency is apparent following radiation-induced injury. [provided by MGI curators] |