| First Author | Cambridge EL | Year | 2017 |
| Journal | Exp Hematol | Volume | 45 |
| Pages | 64-68.e5 | PubMed ID | 27666489 |
| Mgi Jnum | J:236972 | Mgi Id | MGI:5810475 |
| Doi | 10.1016/j.exphem.2016.09.006 | Citation | Cambridge EL, et al. (2017) The AMP-activated protein kinase beta 1 subunit modulates erythrocyte integrity. Exp Hematol 45:64-68.e5 |
| abstractText | Failure to maintain a normal in vivo erythrocyte half-life results in the development of hemolytic anemia. Half-life is affected by numerous factors, including energy balance, electrolyte gradients, reactive oxygen species, and membrane plasticity. The heterotrimeric AMP-activated protein kinase (AMPK) is an evolutionarily conserved serine/threonine kinase that acts as a critical regulator of cellular energy balance. Previous roles for the alpha 1 and gamma 1 subunits in the control of erythrocyte survival have been reported. In the work described here, we studied the role of the beta 1 subunit in erythrocytes and observed microcytic anemia with compensatory extramedullary hematopoiesis together with splenomegaly and increased osmotic resistance. |
