mice infected with the murine hepatitis virus strain 3 (MHV-3) coronavirus exhibit extended survival (up to 10 days compared to 4 in wild-type) and improved liver histology, decreased inflammatory response, and decreased viral titers than wild-type mice, however, infection gradually does lead to widespread liver damage of 40-50% focal necrosis but never as severe as in wild-type mice and mice eventually succumb to infection
