| First Author | Barth RK | Year | 1985 |
| Journal | Nature | Volume | 316 |
| Issue | 6028 | Pages | 517-23 |
| PubMed ID | 2412120 | Mgi Jnum | J:7995 |
| Mgi Id | MGI:56464 | Doi | 10.1038/316517a0 |
| Citation | Barth RK, et al. (1985) The murine T-cell receptor uses a limited repertoire of expressed V beta gene segments. Nature 316(6028):517-23 |
| abstractText | Only 10 different V beta gene segments were found when the sequences of 15 variable (V beta) genes of the mouse T-cell receptor were examined. From this analysis we calculate that the total number of expressed V beta gene segments may be 21 or fewer, which makes the expressed germline V beta repertoire much smaller than that of immunoglobulin heavy-chain or light-chain genes. We suggest that beta-chain somatic diversification is concentrated at the V beta-D beta-J beta junctions. |
