| First Author | Cunliffe V | Year | 1990 |
| Journal | Genomics | Volume | 8 |
| Issue | 2 | Pages | 331-9 |
| PubMed ID | 2249852 | Mgi Jnum | J:10861 |
| Mgi Id | MGI:59306 | Doi | 10.1016/0888-7543(90)90290-b |
| Citation | Cunliffe V, et al. (1990) Genomic analysis of a mouse zinc finger gene, Zfp-35, that is up-regulated during spermatogenesis. Genomics 8(2):331-9 |
| abstractText | Zinc finger genes are a class of eukaryotic regulatory genes that encode sequence-specific nucleic acid-binding proteins. Members of this large gene family are required for growth and development in a wide range of organisms. We previously identified a mouse zinc finger gene, Zfp-35, that was up-regulated during spermatogenesis at the pachytene spermatocyte stage of development. We now describe the genomic organization of this gene, including its intron-exon structure, the sequence of its flanking regions, and its assignment to a region encompassing bands B3 to C of chromosome 18. The transcription unit has three exons. Intron 1 is within the 5' untranslated region and exon 3 contains the block of all 18 zinc fingers. These two features are common to a number of zinc finger genes. We also show that Zfp-35 is conserved in some placental mammals and that it is a member of a subfamily of related mammalian zinc finger genes. |
