| First Author | Brachvogel B | Year | 2002 |
| Journal | Gene | Volume | 288 |
| Issue | 1-2 | Pages | 203-10 |
| PubMed ID | 12034510 | Mgi Jnum | J:77081 |
| Mgi Id | MGI:2180978 | Doi | 10.1016/s0378-1119(02)00508-5 |
| Citation | Brachvogel B, et al. (2002) Molecular cloning and expression analysis of a novel member of the Disintegrin and Metalloprotease-Domain (ADAM) family. Gene 288(1-2):203-10 |
| abstractText | We cloned and characterized the cDNA and the expression pattern of a novel member of the murine 'Disintegrin and Metalloprotease-Domain Family' (ADAM). The predicted protein sequence reveals highest homology to the testase-subgroup, composed of ADAM 24, ADAM 25 and ADAM 26 and is therefore called testase 4. Reverse transcription-polymerase chain reaction showed a strong expression of testase 4 in the adult testis, but not in any other organ or embryonic stage tested. Careful characterization by in situ hybridization confirmed specific expression of testase 4 in maturing sperm cells of 6-week-old mice, whereas no specific hybridization pattern was detectable in testes of 2.5-week-old mice. These data indicate a correlation between testase 4 expression and spermatogenesis and/or fertilization. |
