| Primary Identifier | MGI:108466 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 19765 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables GTPase activator activity and small GTPase binding activity. Predicted to be involved in several processes, including doxorubicin transport; positive regulation of mitochondrial fission; and xenobiotic detoxification by transmembrane export across the plasma membrane. Predicted to be located in mitochondrion; nuclear body; and plasma membrane. Predicted to be active in Schaffer collateral - CA1 synapse and membrane. Human ortholog(s) of this gene implicated in pancreatic adenocarcinoma. Orthologous to human RALBP1 (ralA binding protein 1). PHENOTYPE: Homozygous and heterozygous null mice display increased sensitivity to X-ray irradiation, increased oxidative stress, and impaired glutathione homeostasis. Mice homozygous for a gene trap insertion exhibit decreases in exploratory and locomotor activity and a decreased sensitivity to pain. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
