| Primary Identifier | IPR031248 | Type | Family |
| Short Name | RNF213 |
| description | RNF213 functions as ubiquitin ligase and AAA+ ATPase, and plays a role in vascular development through mechanical processes in the cell []. It contains a RING finger domain, which is a well-established ubiquitin ligase domain that covalently modifies substrate proteins with ubiquitin and stimulates the proteasomal protein degradation. It also functions as an ATPase through its AAA+ ATPase modules []. The RNF213 gene is a susceptibility gene for moyamoya disease, an idiopathic vascular disorder of intracranial arteries []. |
