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Publication : The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation.

First Author  Ng SS Year  2020
Journal  Nat Immunol Volume  21
Issue  10 Pages  1205-1218
PubMed ID  32839608 Mgi Jnum  J:301637
Mgi Id  MGI:6506882 Doi  10.1038/s41590-020-0758-6
Citation  Ng SS, et al. (2020) The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation. Nat Immunol 21(10):1205-1218
abstractText  Immune-modulating therapies have revolutionized the treatment of chronic diseases, particularly cancer. However, their success is restricted and there is a need to identify new therapeutic targets. Here, we show that natural killer cell granule protein 7 (NKG7) is a regulator of lymphocyte granule exocytosis and downstream inflammation in a broad range of diseases. NKG7 expressed by CD4(+) and CD8(+) T cells played key roles in promoting inflammation during visceral leishmaniasis and malaria-two important parasitic diseases. Additionally, NKG7 expressed by natural killer cells was critical for controlling cancer initiation, growth and metastasis. NKG7 function in natural killer and CD8(+) T cells was linked with their ability to regulate the translocation of CD107a to the cell surface and kill cellular targets, while NKG7 also had a major impact on CD4(+) T cell activation following infection. Thus, we report a novel therapeutic target expressed on a range of immune cells with functions in different immune responses.
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